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In fewer than 1% of people taking the drug, changes in blood pressure, redness and itching of the eyes, altered taste, altered smell, gas, changes in appetite, rectal bleeding, changes in urination patterns, menstrual irregularity, muscle cramps, muscle spasms, shortness of breath, changes in sex drive, allergic reactions, dry skin, weight changes (both gains and losses), and malaise were reported.

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Do not use carbidopa and levodopa if you have used an MAO inhibitor in the past 14 days.

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The levels of the aberrant proteins that lead to neuronal disruption were also tested in the brains of mice.

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Carbidopa inhibits aromatic-L-amino-acid decarboxylase, an enzyme important in the biosynthesis of L-tryptophan to serotonin and in the biosynthesis of L-DOPA to Dopamine (DA).

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In another aspect there is provided a single oral dose pharmaceutical composition comprising entacapone, levodopa and carbidopa, or pharmaceutically acceptable salts or hydrates thereof and microcrystalline cellulose, wherein a substantial portion of carbidopa or a pharmaceutically acceptable salt or hydrate thereof is separated from a mixture of entacapone and levodopa or pharmaceutically acceptable salts or hydrates thereof.

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